The Ms. wrote:
Question: In your experience how many have a real biological issue. My niece was uncomfortable being female from time she was 2…..when she was 18 she became a boy. Thank You.
First, a bit of background: I grew up in a family where nobody seems to have ever thought of changing g****r. One of my relatives was a tomboy and may have later regretted having been a tomboy, but that doesn't count (because it seemed to be within the bounds of normalcy). Among all the kids I saw at grade school, they all looked normal sexually. So, there's nothing particularly unusual about my background.
Among the 15 (fifteen) or so people I've gotten to know the closest, two did have a real biological issue sexually, that I know about. So, if there were no medical interventions, those two might possibly have qualified as non-standard-g****red (because of the internal biological (hormonal) difference). In both cases the difference was changed, or "corrected", to make the person more "normal", and this was done by hormonal adjustment, nothing more. I can tell you that to the affected individual, it makes a big difference _when_ the hormonal adjustment is done, and it can be a rather personal matter. A delay of a few extra years can make a difference in how the person adapts or thinks about the self and others -- maybe in terms of self-esteem.
Aside from all that, I don't recall any other "real biological issue" with sexuality, in my experience.
If you're willing to believe experts, I think you could get better estimates of how often differences occur. I went to a 2-hour seminar once (20 years ago) about people who are gay (or "homosexual" or "gay and lesbian"). The seminar leader was a lesbian teacher from a local college. If I recall correctly, she said that if you have two children, then there's a 25% chance that at least one of them will be a non-standard g****r (which meant gay, lesbian, or bi-sexual).
That part is probably not the kind of "real biological issue" you asked about, though. I just wanted to talk about it anyway.
Of the roughly 150 (one hundred fifty) people closest to me in acquaintance, right now I remember three who were gay and said so; one was one of my roommates at college; one was one of my officemates at work, and one was another person in my branch at work. (Oh, now I'm remembering at least two more. They are more recent acquaintances.)
Much later, when I was learning some dancing, I joined a class that was mostly gay people, because it was teaching at the level I needed. The ones in the dance class were not in my "150 people closest to me in acquaintance". I didn't get to know them quite as well.
_All_ the gay (or homosexual or lesbian) people I've met have been nice people, with the usual talents people have, if not more, and I'm happy to have been acquainted with them all. (The other main non-standard g****rs I've heard about are asexual and bisexual but I either never met one of them or just didn't know that about them. There's also "polyamorous" but maybe that's not a g****r.)
And, by the way, in case anyone's wondering, one can dance with a gay person and it doesn't change anything. It doesn't turn you into a gay person. They're either a good dancer or not, just like anyone else. That said, for completeness I would have to admit that when I dance many times with a woman (I'm male heterosexual) in couples dancing, I do occasionally develop a sexual attraction to the dance partner. So, presumably, if I were gay or bisexual, the same could happen if I were dancing with one same-sex partner a lot.
During middle age, one of my friends told me that she had two children, a boy and a girl, and both of them were gay. The only reason I know is that she mentioned it to me. I never got to know her children. She was heterosexual, or at least had all the appearances of being so. If she were lesbian or bisexual I think she'd have told me.